Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder

Circadian rhythms and sleep in bipolar disorder.

OBJECTIVE Biological rhythm pathways are highlighted in a number of etiological models of bipolar disorder, and the management of circadian instability appears in consensus treatment guidelines. There are, however, significant conceptual and empirical limitations on our understanding of a hypothesised link between circadian, sleep, and emotion regulation processes in bipolar disorder. The aim o...

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

BACKGROUND Bipolar disorder (BPD) is a widespread condition characterized by recurring states of mania and depression. Lithium, a direct inhibitor of glycogen synthase kinase 3 (GSK3) activity, and a mainstay in BPD therapeutics, has been proposed to target GSK3 as a mechanism of mood stabilization. In addition to mood imbalances, patients with BPD often suffer from circadian disturbances. GSK3...

Lithium treatment for bipolar disorder.

This section looks back to some of the ground-breaking contributions to public health, reproducing them in their original form and adding a commentary on their significance from a modern-day perspective. To complement this month’s theme of the Bulletin, Philip B. Mitchell and Dusan Hadzi-Pavlovic review the 1949 paper by John F.J. Cade on the use of lithium salts in the treatment of psychotic e...

Circadian Rhythm and Bipolar Disorder Impact of Circadian Rhythm Disturbances in Bipolar Disorder

Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation.

Despite advances in the treatment of bipolar disorder, a significant proportion of patients experience disabling symptoms between episodes, and relapse rates are high. These circumstances suggest that there is a critical need to achieve a mechanistic understanding of triggers of relapse and to target them with specific, empirically derived treatments. Sleep disturbances are among the most promi...